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KMID : 0368019890120030243
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Journal of Soonchunhyang University
1989 Volume.12 No. 3 p.243 ~ p.250
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Effects of the Ginseng Extract on the r-Glutamyl Transpeptidase activity of the Ethanol-Administered Rats
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조만희/Cho, Man-Hee
신경현/이상한/김창세/Shin, Kyung-Hyun/Lee, Sang-Han/Kim, Chang-Se
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Abstract
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This study was carried out to investigate the effects on the changes of the r-glutamyl transoeotidase activity of ethanol-administered white rats.
There was classified into four groups; ethanol treated group(group A), ethanol treated group which was pretreated with ginseng extract(group B), ginseng extract treated group(group C), and genseng extract treated group which was pretreated with ethanol(group D).
White rats of four groups were treated with combined 1% ginseng extract and / or 20% ethanol for 30 days, and were measured the changes of r-GTP activity on the serum, hepatic and renal tissue sample collected at 5 days interval.
Following results have been obtained.
1. The changes of serum r-GTP activity were significantly decreased in ethanol treated group B which was pretreated with ginseng extract than in ethanol treated group A. The values were highly significant at the 20th day of feeding.
2. The changes of hepatic r-GTP activity were more increased in group A and decreased in group D. The values were found significantly lowest in 10th and highest in 5th days.
3. The changes of renal r-GTP activity were more increased in group A and decreased in group D. The values were significantly highest in 10th and lowest in 20th days.
Based on these results it was found that the changes of r-GTP activity between serum and hepatirenal tissue were exist and the protective action of ginseng against alcohol degradative effect was noted.
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